Clinicopathologic Integration and Sex-Difference Research

What this project does
Links post-mortem pathology with clinical, imaging, and biomarker data to study disease heterogeneity and sex-based biological differences.

Why it matters clinically
Many patients have multiple overlapping pathologies; understanding how these differ between women and men improves diagnosis and precision medicine approaches.

Key activities
-Integrate pathology data with: longitudinal clinical assessments, neuroimaging findings, biomarker profiles
-Support studies focused on sex differences in AD/ADRD pathogenesis and progression

What will be delivered
-Clinicopathologic correlation datasets
-Evidence clarifying biological contributors to sex differences in ADRD

Who this helps
-Clinicians interpreting complex or mixed dementia presentations
-Researchers developing sex-informed diagnostic and therapeutic strategies