Studying Sex-Based Differences in ADRD Biology and Progression

What this project does
Examines how biological sex influences cognition, progression, and underlying disease mechanisms.

Why it matters clinically
Women and men differ in risk, pathology, and progression—understanding these differences is essential for personalized diagnosis and treatment.

Key activities
-Analyze sex differences in baseline cognition and longitudinal decline
-Integrate clinical data with neuroimaging measures, immune and inflammatory biomarkers, vascular risk factors, endocrine status, α-synuclein status from skin biopsies
-Collaborate closely with Biomarker and Neuroimaging Cores

What will be delivered
-Sex-specific clinical-biological profiles
-Evidence supporting sex-informed diagnostics and therapies

Who this helps
-Clinicians treating diverse ADRD patients
-Researchers developing precision medicine approaches