Vascular Injury Biomarkers Without Extra Procedures

What this project does
Measures vascular injury and endothelial/BBB-related biomarker signals using existing blood/CSF samples—so participants don’t need extra draws or procedures.

Why it matters clinically
Vascular disease often co-exists with AD and changes trajectory and symptom burden. This helps separate “pure AD biology” from mixed vascular contributions, and may clarify sex-based differences.

Key activities
-Quantify vascular-relevant proteins included in the same proteomics panel (including MarkVCID-recommended markers)
-Integrate these measures with: vascular risk factors collected clinically, MRI markers of vascular injury (via Imaging Core), postmortem validation when available (Neuropathology Core)

What will be delivered
-Vascular biomarker profiles linked to clinical vascular risk and imaging markers
-Better characterization of mixed dementia biology in the cohort

Who this helps
-Clinicians managing patients with overlapping AD + vascular disease
-Researchers studying mixed etiologies