Sex-Specific Inflammation Profiling

What this project does
Profiles immune and inflammatory signals in blood and CSF to identify immune pathways that differ between women and men with MCI due to AD.

Why it matters clinically
Inflammation likely contributes to differences in risk and progression. Identifying sex-specific immune signatures can help explain why disease course differs and may inform targeted therapies.

Key activities
-Use large-scale proteomic panels (plasma ± CSF) to profile central and peripheral inflammatory markers
-Identify inflammatory pathways and patterns that are different in women vs men
-Relate immune profiles to disease stage, cognition, and progression over time

What will be delivered
-Sex-stratified immune biomarker profiles
-Candidate inflammatory signatures that may predict progression or subtypes

Who this helps
-Clinicians interested in “why patients differ” even with similar diagnoses
-Researchers developing precision medicine biomarkers